Domustyche Guest House

5 Via Sebastiano Grandis, Esquilino, Rome, Italy - Close to attractions
9.4/10 · 124 reviews

Located just 6 minutes by foot from the 4-star Domustyche Guest House Rome, guests can quickly reach the erroneously named Temple of Minerva Medica. There is also a car park.

Location

This comfortable guest house offers a prime location in Rome, 0.3 miles from the monumental cathedral "Basilica di San Giovanni in Laterano", and 1.7 miles from the large sunny square "Piazza Venezia". Located about a 10-minute stroll from Manzoni metro station, the Domustyche Guest House Rome is about 10 minutes by car from Borghese Gallery and Museum. Along with other cultural attractions Castel Sant'Angelo Museum is nestled 2.6 miles from the Rome hotel. The property lies in the vicinity of Flaminio train station, and the ancient Colosseum Roman Amphitheatre is situated a 19-minute stroll away.

Rooms

The rooms feature such facilities as coffee and tea making equipment, along with a flat-screen TV with satellite channels for guests' entertainment. Climate control are featured for guests' comfort. The private bathrooms with a bidet, a separate toilet, and a shower also offer a hairdryer and bath sheets. Enjoy views of the town, while staying at the Domustyche Guest House.

Food & Drinks

You may walk 5 minutes to Osteria La Sol Fa or eat by Bottega Trattoria De Santis, located approximately 300 feet away.

Why choose Domustyche Guest House Rome

Select room

  • Free WiFi throughout the property

  • Family rooms available

  • Air conditioning in each room

  • Flat-screen TV in all rooms

Main amenities

  • Wi-Fi

  • Child-friendly

  • Air conditioning

  • No pets allowed

General
  • Wi-Fi
  • Child-friendly
  • Air conditioning
  • No pets allowed
1/10

Internet

  • Wi-Fi

Parking options

  • Parking

Property services

  • Security

In the kitchen

  • Shared kitchen
  • Electric kettle

For kids

  • Cots

In the rooms

  • Air conditioning
  • Heating

In the bathroom

  • Free toiletries

Devices

  • Flat-screen TV

General facilities

  • No smoking on site
  • Lift
  • Smoke detectors
  • Fire extinguishers
  • Key access

Pets

  • No pets allowed

Important information

Check-in:
from 14:00 until 22:00
Check-out:
until 10:00
License number35398,IT058091B45RY32CGL

Enter dates to see availability

From USD 163 per night
Check-in 19 Oct 2026
Check-out 20 Oct 2026
Guests 2 guests

Adults:

2

Children:

0
All rates verified
How we verified prices Our team regularly checks prices to make sure you see the lowest available rates. We compare them with hotel prices and other providers. If discounts or promotions appear, prices on our site are updated accordingly.

Rooms

Current offers Editor's Pick
Up to 15% off

Longer Stays

A few extra nights let you slow down, find favorite spots, and experience the place beyond the highlights.
5 nights or more Discount will be applied to your results
Up to 10% off

Mobile Rates

Book in a few taps and save a little more for the places, tastes, and moments waiting throughout your stay.
Book via mobile Includes special rates from Booking.com
Up to 20% off

Early Bird

Reserve while the right dates are open, then enjoy planning everything that comes after stress-free, step by step.
Book 30+ days ahead Some dates already include an extra discount

Photos of Domustyche Guest House Rome

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Domustyche Guest House
Domustyche Guest House
Domustyche Guest House
Domustyche Guest House

Domustyche Guest House Rome

Hotel offering convenient rooms and shared kitchen

Gallery

Domustyche Guest House

Guest house Domustyche
Domustyche Guest house
Domustyche 4*
Domustyche Guest house 4*
Domustyche 4* Rome
Guest house Domustyche 4*
Domustyche Guest house
Guest house Domustyche 4*
Domustyche Guest house
Guest house Domustyche 4*
Guest house Domustyche
Domustyche Guest house
Guest house Domustyche
Domustyche Guest house Rome
Domustyche Guest house
Domustyche Guest house Rome
Guest house Domustyche Rome
Guest house Domustyche Rome
Domustyche Guest house
Domustyche
Domustyche Guest house 4*
Domustyche
Domustyche Guest house 4*
Domustyche Guest house Rome
Domustyche

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Location of Domustyche Guest House Rome

5 Via Sebastiano Grandis, Esquilino, Rome, Italy

 -  Close to attractions
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    Guest reviews of Domustyche Guest House Rome

    Based on ratings from trusted providers

    9.4 /10
    Superb 124 reviews
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          100% Verified Reviews
          Enter dates to see availability
          From USD 163 per night
          Check-in 19 Oct 2026
          Check-out 20 Oct 2026
          Guests 2 guests

          Adults:

          2

          Children:

          0
          All rates verified
          How we verified prices Our team regularly checks prices to make sure you see the lowest available rates. We compare them with hotel prices and other providers. If discounts or promotions appear, prices on our site are updated accordingly.
          Check-in & out
          19 Oct 2026
          —
          20 Oct 2026
          Guests
          2 guests
          Check availability
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          Important information
          Domustyche Guest House
          Check-in:
          from 14:00 until 22:00
          Check-out:
          until 10:00
          License number35398,IT058091B45RY32CGL